Stiffness is a common problem after fasciectomy, particularly loss of flexion, and can be resistant to stretching exercises or splints. This therapy program, incorporating a combination of casting and active exercises, helped patients regain motion when they had failed conventional hand therapy: http://www.dupuytrenfoundation.org/DupPDFs/2007_Rose.pdf
Read more › The source of medical information is critical; objectivity is essential. That’s one of the advantages of the UK’s NHS independent review process. Read their assessment of needle aponeurotomy:http://www.dupuytrenfoundation.org/DupPDFs/2004_NICE.pdf
Read more › Looking for ways to stop Dupuytren’s, it should be useful to look in reverse at factors which may start it, such as protease inhibitor drugs, as reported here: http://www.dupuytrenfoundation.org/DupPDFs/2002_Florence_1607.pdf
Read more › Dupuytren’s is not always painless. Sometimes, active areas itch and burn. This goes along with the finding of elevated levels of mast cells and nerve fibers containing substance P – something also found in interstitial cystitis. Find out more at http://www.dupuytrenfoundation.org/DupPDFs/2006_Schubert_1071.pdf
Read more › This report of Dupuytren’s extending from the palm into the forearm reviews the anatomy of involvement and points out the aggressive nature of Dupuytren’s in young people. We need more effective biologic treatments: http://www.dupuytrenfoundation.org/DupPDFs/1997_Sinha_1048.pdf
Read more › This is a classic article on the biology of Dupuytren’s. Structural changes in the palmar fascia are associated with type III collagen, which isn’t normally found in this tissue. Myofibroblasts are likely the source of this and are associated with disease recurrence.Most important quote: “Clinical recurrence was not related to the age ofthe patient at […]
Read more › The website for the 2010 International Symposium on Dupuytren’s Disease is now live, accepting on line registration and submission of abstracts for presentation. http://www.DupuytrenSymposium.com
Read more › It’s taken almost two years to wade through the red tape, but hot off the press, The Dupuytren Foundation is finally officially certified as a 501(c)3 Public Charity! See https://dupuytrens.org/dupfoundation501c3.pdf for documentation.
Read more › Skin grafting is a time honored technique in the range of options to reduce the incidence of recurrence after fasciectomy for Dupuytren’s contracture. There are two general approaches. One is dermofasciectomy: remove a large area of affected skin and resurface the area with a similarly large skin graft. The other is to put in a […]
Read more › The goal of the collaboration of the Dupuytren Foundation and Scripps Research is to identify the genes responsible for Dupuytrens and then develop a targeted intervention to make them stop doing that. Our DNA is like a computer, and our genes are the programs that are either running (upregulated) or not running (downregulated). The genes […]
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