General

Drugs that provoke Dupuytren’s Disease
On: Nov 6, 2009
By: Charles Eaton

Looking for ways to stop Dupuytren’s, it should be useful to look in reverse at factors which may start it, such as protease inhibitor drugs, as reported here: http://www.dupuytrenfoundation.org/DupPDFs/2002_Florence_1607.pdf

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Dupuytren’s, Mast cells, Substance P
On: Nov 6, 2009
By: Charles Eaton

Dupuytren’s is not always painless. Sometimes, active areas itch and burn. This goes along with the finding of elevated levels of mast cells and nerve fibers containing substance P – something also found in interstitial cystitis. Find out more at http://www.dupuytrenfoundation.org/DupPDFs/2006_Schubert_1071.pdf

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Aggressive Dupuytren’s Disease
On: Nov 6, 2009
By: Charles Eaton

This report of Dupuytren’s extending from the palm into the forearm reviews the anatomy of involvement and points out the aggressive nature of Dupuytren’s in young people. We need more effective biologic treatments: http://www.dupuytrenfoundation.org/DupPDFs/1997_Sinha_1048.pdf

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Dupuytren’ s Contracture – Microscopic Analysis
On: Nov 6, 2009
By: Charles Eaton

This is a classic article on the biology of Dupuytren’s. Structural changes in the palmar fascia are associated with type III collagen, which isn’t normally found in this tissue. Myofibroblasts are likely the source of this and are associated with disease recurrence.Most important quote: “Clinical recurrence was not related to the age ofthe patient at […]

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Dupuytren Symposium Website is Live!
On: Sep 19, 2009
By: Charles Eaton

The website for the 2010 International Symposium on Dupuytren’s Disease is now live, accepting on line registration and submission of abstracts for presentation. http://www.DupuytrenSymposium.com

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Dupuytren Foundation is now a Public Charity
On: Jul 4, 2009
By: Charles Eaton

It’s taken almost two years to wade through the red tape, but hot off the press, The Dupuytren Foundation is finally officially certified as a 501(c)3 Public Charity! See https://dupuytrens.org/dupfoundation501c3.pdf for documentation.

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Dupuytren’s Skin Graft Controversy
On: Apr 10, 2009
By: Charles Eaton

Skin grafting is a time honored technique in the range of options to reduce the incidence of recurrence after fasciectomy for Dupuytren’s contracture. There are two general approaches. One is dermofasciectomy: remove a large area of affected skin and resurface the area with a similarly large skin graft. The other is to put in a […]

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Genetic studies are underway for Dupuytren’s
On: Apr 8, 2009
By: Charles Eaton

The goal of the collaboration of the Dupuytren Foundation and Scripps Research is to identify the genes responsible for Dupuytrens and then develop a targeted intervention to make them stop doing that. Our DNA is like a computer, and our genes are the programs that are either running (upregulated) or not running (downregulated). The genes […]

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On: Apr 6, 2009
By: Charles Eaton

Hand therapy and splinting are usually a big part of recovery after open surgery for Dupuytren’s contracture. Despite a drive for evidence based medicine, evidence for the effectiveness of splinting after open Dupuytren’s surgery is still elusive. Debbie Larson and Christina Jerosch-Herold review the issue in this article (link to full text pdf): Clinical effectiveness […]

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