Blog
Oxygen Free Radicals and Dupuytren’s
Oxygen free radicals affect Dupuytren’s fibroblasts: high levels are toxic, but not only do slightly elevated levels stimulate fibroblast activity, active fibroblasts actually produce oxygen free radicals. Which is the chicken and and which is the egg? This seminal paper reports studies of the effects of oxygen free radicals on
Viking blood, blue eyes and other risk factors for Dupuytren’s
What is the actual story of the Vikings and Dupuytren’s? The full history will never be known, but some fascinating details on this and other risk factors, including blue eyes, are reviewed here: https://www.dupuytrens.org/DupPDFs/2001_Flatt_1397.pdf. See page 4 for a decision tree showing how to predict the risk of recurrence after
Sorting out the truth
Don’t believe everything you read about Dupuytren’s – even in respectable journals. I was aware that reflex sympathetic dystrophy (complex regional pain syndrome) was more common after fasciectomy for Dupuytren’s than for other hand operations, but there is little published on this. Then, this report came out documenting surprisingly high
Lessons from Peyronie’s for Dupuytren’s
Peyronie’s disease is more common than Dupuytren’s – 3 to 9 percent of the population – and shares a similar biology and genetic predisposition. Progress in the treatment of Peyronie’s will benefit that of Dupuytren’s and vice versa. Taken in this context, these two articles by Hellstrom from 2000 and
Looking at Dupuytren’s with MRI
Where is Dupuytren’s? It’s been known for some time that Dupuytren’s involvement can be identified by MRI, as described in these articles:https://www.dupuytrens.org/DupPDFs/1993_Yacoe_813.pdfhttps://www.dupuytrens.org/DupPDFs/1994_Miller.pdfand it’s likely that the activity of the process could be mapped, both for predictive value and for targeted treatment to prevent progression. Now, these papers are 15 years
The Fish Technique for Dupuytren’s: Fasciectomy and Skin Graft
Skin grafts are used in a variety of approaches for Dupuytren’s: to add skin where it has been shortened (fasciotomy and skin graft, fasciectomy and skin graft); to replace skin where it has been removed to prevent recurrence (dermofasciectomy and skin graft). This study reviews the results of fasciectomy and
Accidental fasciotomy for Dupuytren’s
Fingers bent by Dupuytren’s can complicate a fall on an outstretched hand: because the fingers can’t stretch back, the force of impact is redistributed, making it more likely to break hand bones. When the fall is hard enough to break something, occasionally what gives is not bone, but the Dupuytren
No advantage to open Proximal Interphalangeal Joint release for Dupuytren’s
Proximal interphalangeal joint contractures from Dupuytren’s disease take on a life of their own, persisting after the Dupuytren’s has been removed. One of the arguments for open fasciectomy is that PIP contractures can be treated by openly releasing the tight joint capsule and ligaments. Unfortunately, gains made in the operating
Dupuytren’s and Burns
Dupuytren’s overlaps in some ways with the local excessive scarring which occur after a burn injury. This report documents the development of progressive Dupuytren’s disease developing in a young man after a hand burn, and reviews the conventional teachings regarding Dupuytren’s: https://www.dupuytrens.org/DupPDFs/2008_Balakrishnan_1422.pdf
Recent Dupuytren Publications
- The diabetic hand - a forgotten complication
- Dupuytren's disease : Epidemiology, diagnosis, treatment, outcome
- Dupuytren's disease and occupational mechanical exposures: a systematic review and meta-analysis
- Use of 3D printing technology for custom bolus fabrication in the management of palmar or plantar fibromatosis with radiotherapy: A retrospective case series
- The 'Universal Approach' for Dupuytren's disease: A safe and reproducible sequence for planning fasciectomy incisions
