Dupuytren’s is not always painless. Sometimes, active areas itch and burn. This goes along with the finding of elevated levels of mast cells and nerve fibers containing substance P –

This report of Dupuytren’s extending from the palm into the forearm reviews the anatomy of involvement and points out the aggressive nature of Dupuytren’s in young people. We need more

This is a classic article on the biology of Dupuytren’s. Structural changes in the palmar fascia are associated with type III collagen, which isn’t normally found in this tissue. Myofibroblasts