The goal of the collaboration of the Dupuytren Foundation and Scripps Research is to identify the genes responsible for Dupuytrens and then develop a targeted intervention to make them stop doing that. Our DNA is like a computer, and our genes are the programs that are either running (upregulated) or not running (downregulated). The genes that result in Dupuytren’s are chromosomal malware – a bad program or bad programs. Progress is being made http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2377253&blobtype=pdf with a small number of samples. The Scripps DNA project anticipates a DNA sample selection 10 to 100 times larger than what has been previously available. The future looks bright. We will find a cure.