Solving The Dupuytren Puzzle

Notes on theories of the origin of Dupuytren disease.

Any theory of the core biology of Dupuytren disease has to explain these factors:

  • Familial influence
  • Age influence
  • Gender Influence
  • Relationship to mechanical forces
  • Transformation of adjacent tissues
  • Myofibroblast persistence
  • Variability
  • Appearance only at certain locations
  • Quiescence

Starting Points: The matrix is abnormal. The cells are abnormal. Which comes first?

Abnormal Matrix

Abnormal local cells

Unexplained biologic comorbidities – what explains these?

Unexplained lifestyle comorbidities – are these real? What is their role?

Dupuytren Literature