Dupuytren’s Contracture

Is Dupuytren’s an immune problem?
Feb 19, 2010

Is Dupuytren’s an autoimmune or an allergic condition? In some fibrotic diseases, such as endomyocardial fibrosis, tissues show activity of eosinphils. Eosinophils are normally found in small numbers in the bloodstream. They are part of the immune system and are abnormally involved in some medical conditions such as asthma. Eosinophils are filled with little bags […]

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Similar genes found in Dupuytren’s and Peyronie’s

Dupuytren’s and Peyronie’s disease are believed to be related, to share a common genetic starting point. This has been an assumption, not hard fact: the genetic starting points of these conditions are not yet known, much less known to be the same. Doctors have been wrong on these issues in the past: in the 1800’s, […]

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Xiaflex Pricing

Auxilium has moved closer to product availability of Xiaflex collagenase injection for the treatment of Dupuytren’s contracture by announcing the wholesale drug price: $3250.00 for a single treatment dose. For those who think that this seems high, consider this in perspective. There are many categories of pharmaceutical products. Most commonly available pharmaceuticals are classified as […]

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Dupuytren’s Demographic Data
On: Feb 16, 2010
By: Charles Eaton

While researchers look through the microscope at the cellular biology of Dupuytren’s, surgeons look for clues using the fish eye lens of demographic observations. Who is at risk? What family, lifestyle, medication and medical condition issues affect the incidence and magnitude of Dupuytren’s? There is a long history of these questions and observations. A typical […]

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RNA, Growth Factors and Dupuytren’s

Sorting out the genetic basis of Dupuytren’s is not simply a matter of finding out which genes are involved. The goal is to understand the biochemistry of exactly what these specific genes do to either start or fail to stop the process of Dupuytren’s. Cell biology is always a domino like set of events with […]

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Dupuytren’s Diathesis

What is Dupuytren’s Diathesis? Diathesis is a medical term meaning tendency toward a condition. One way of describing a person with Dupuytren’s diathesis is that they have more of whatever Dupuytren’s is. Diathesis usually means more aggressive Dupuytren’s: earlier age of onset; more fingers involved; more often bilateral; faster progression; more recurrence problems. The hallmark […]

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Needle Aponeurotomy and Xiaflex compared

Xiaflex (Collagenase) has finally been approved by the FDA for the treatment of Dupuytren’s contracture. When work began on the development of collagenase to treat Dupuytren’s contracture, the bar was pretty low: anything better than fasciectomy in terms of either safety or efficacy would be a great advance. No other treatment options were available in […]

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Growing bent fingers straight
On: Feb 13, 2010
By: Charles Eaton

Two things are needed for people dealing with Dupuytren’s: a way to reverse or restore fingers back to their natural state and a way to prevent progression/recurrence. For the former, progress is being made; the latter remains the elusive goal of a cure. Dupuytren’s is a shrinking process. The ideal treatment would be to reverse […]

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Cellular biomechanics are the key to Dupuytren’s.

Dupuytren’s is truly a biomechanical process, and the ultimate process has to do with the way that fibroblasts and myofibroblasts attach to each other and physically attach to strands of collagen and other components of the tissue matrix which surrounds them. An investigation into the complex junction of living cells, strings of proteins and mechanical/chemical […]

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Fasciectomy: Unsafe at any Speed?

Fasciectomy, invented by Goyrand just a few years after Dupuytren’s initial demonstration of open fasciotomy, has been the main treatment option for Dupuytren’s for nearly 200 years. There have been many refinements, but the central theme of removing fascia is unchanged. With so much time and experience, one might assume that all of the wrinkles […]

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