A specific gene has not been definitively associated with Dupuytren’s, but the best evidence suggests that the primary cause is genetic. There are factors which alter risk, such as diabetes and local trauma, but these are minor compared with the underlying genetic risk. The question of causation is not simply academic: since the time of Dupuytren, lawsuits have been filed to claim payment for Dupuytren’s Disease as a work-related injury. Unlike the laws of Man, the laws of Nature are not altered by argument, but the courts continue to debate the issue, as shown in this recent court document: https://www.dupuytrens.org/DupPDFs/2008_Bridgett.pdf
