Myofibroblast Biology

Myofibroblast biology is at the heart not only of Dupuytren’s, but of other diseases not related to Dupuytren’s. Myofibroblasts are major players in pulmonary fibrosis, cirrhosis, renal fibrosis and arteriosclerosis. Studies of myofibroblast biology in these conditions may shed light on potential new treatment strategies for Dupuytren’s. Gains in the management of any one myofibroblast related condition may benefit others. This review paper covers myofibroblast biology outside the realm of Dupuytren’s and a number of possible targets for biological intervention – for example: could topical nitroglycerin work for Dupuytren’s?