General

Genetic determined biochemistry and Dupuyren’s
By: Charles Eaton
Nov 13, 2009

The genetic basis of Dupuytren’s is explained by the genetic basis of individual biochemistry and enzymatic variation. Sort of. This fascinating review shows how complicated this can be: http://www.dupuytrenfoundation.org/DupPDFs/2008_Zyluk.pdf

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Verapamil, tamoxifen, carnitine – options?
On: Nov 12, 2009
By: Charles Eaton

One resource for potential medical treatment of Dupuytren’s is the literature on medicines which work for related conditions such as Peyronie’s. This review examines the rationale and results of propionyl-L-carnitine, acetyl-L-carnitine, verapamil and tamoxifen in treating Peyronie’s disease. Is there a role for these in Dupuytren’s? http://www.dupuytrenfoundation.org/DupPDFs/2002_Cavallini.pdf

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Peyronie’s Disease and Dupuytren’s
On: Nov 9, 2009
By: Charles Eaton

Dupuytren’s is one manifestation of a systemic fibrotic disorder that can also show up as Ledderhose, frozen shoulder or Peyronie’s disease. Fortunately, the majority of people affected show only one of these conditions, but many have to deal with several or all of these. This summary reviews the condition referred to as Peyronie’s disease: http://www.dupuytrenfoundation.org/DupPDFs/2009_NIDDK.pdf

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CMMS therapy for stiffness after fasciectomy for Dupuytren’s
On: Nov 6, 2009
By: Charles Eaton

Stiffness is a common problem after fasciectomy, particularly loss of flexion, and can be resistant to stretching exercises or splints. This therapy program, incorporating a combination of casting and active exercises, helped patients regain motion when they had failed conventional hand therapy: http://www.dupuytrenfoundation.org/DupPDFs/2007_Rose.pdf

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Drugs that provoke Dupuytren’s Disease
On: Nov 6, 2009
By: Charles Eaton

Looking for ways to stop Dupuytren’s, it should be useful to look in reverse at factors which may start it, such as protease inhibitor drugs, as reported here: http://www.dupuytrenfoundation.org/DupPDFs/2002_Florence_1607.pdf

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Dupuytren’s, Mast cells, Substance P
On: Nov 6, 2009
By: Charles Eaton

Dupuytren’s is not always painless. Sometimes, active areas itch and burn. This goes along with the finding of elevated levels of mast cells and nerve fibers containing substance P – something also found in interstitial cystitis. Find out more at http://www.dupuytrenfoundation.org/DupPDFs/2006_Schubert_1071.pdf

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Aggressive Dupuytren’s Disease
On: Nov 6, 2009
By: Charles Eaton

This report of Dupuytren’s extending from the palm into the forearm reviews the anatomy of involvement and points out the aggressive nature of Dupuytren’s in young people. We need more effective biologic treatments: http://www.dupuytrenfoundation.org/DupPDFs/1997_Sinha_1048.pdf

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Dupuytren’ s Contracture – Microscopic Analysis
On: Nov 6, 2009
By: Charles Eaton

This is a classic article on the biology of Dupuytren’s. Structural changes in the palmar fascia are associated with type III collagen, which isn’t normally found in this tissue. Myofibroblasts are likely the source of this and are associated with disease recurrence.Most important quote: “Clinical recurrence was not related to the age ofthe patient at […]

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Dupuytren Symposium Website is Live!
On: Sep 19, 2009
By: Charles Eaton

The website for the 2010 International Symposium on Dupuytren’s Disease is now live, accepting on line registration and submission of abstracts for presentation. http://www.DupuytrenSymposium.com

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