Genetics | Dupuytren Research Group

Genetics

2018 Father’s Day

Father’s Day is this weekend! Fathers pass on so many things to their children – wisdom, bad jokes, and sometimes Dupuytren disease. Over half of people with Dupuytren disease know a family member with Dupuytren. Dupuytren Celebrities  This Father’s Day, these celebrities share their experiences with Dupuytren in their families. Joe Bonsall, country music legend […]

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A Meaningful Father’s Day
On: Jun 13, 2017
By: Charles Eaton

A Meaningful Father’s Day Father’s Day is almost here, a time for family remembrance of things passed through generations. Dupuytren disease also passes through generations. A parent with Dupuytren gives each child about one in four chance of eventually having the disease. More fathers than mothers have Dupuytren disease. Dupuytren makes every Father’s Day a […]

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Three types of Dupuytren disease?

It’s important to understand the difference between Dupuytren disease (any Dupuytren like changes in the hand – with or without contracture) and Dupuytren contracture (a bent finger due to Dupuytren like changes). An unsolved issue is variability of disease. It is not known what percent of people with early Dupuytren changes (a lump, a cord without contracture) will […]

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Blue Eyes, Dupuytren Disease, and Alcoholism
On: Jul 19, 2015
By: Charles Eaton

  A recent study linked blue eyes with genetic risk for alcoholism. Interesting, because Dupuytren disease is more common in people with light colored eyes and according to some studies, Dupuytren is linked to chronic alcoholism. It’s a match! Or is it? Other studies conclude alcoholism is not a risk for Dupuytren disease. Both Dupuytren and blue eyes are more common in […]

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2015 Dupuytren Symposium
2015 International Symposium on Dupuytren Disease

The May 2015 International Dupuytren Symposium in Groningen, The Netherlands was very productive. A textbook based on the proceedings is in the works. Video presentations are rolling out on http://Dupuytren.tv

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The earliest case of Dupuytren’s? You’ll never guess where.
On: Mar 7, 2010
By: Charles Eaton

A case of Dupuytren’s contracture has been discovered dating back nearly three thousand years. The Monthemhat Project, a multinational Egyptology group, recently published an analysis of 18 mummies from the Third Intermediate Period from the Luxor Cachette, and report the diagnosis of Dupuytren’s contracture involving the left hand of one of the mummies. The full […]

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Dupuytren’s and Transforming Factor Beta Genetics

What is the initial abnormality which ultimately results in Dupuytren’s? Because biologic systems are guided by tiny triggers which start a cascading series of events, tiny differences can have large effects, and the hunt is sometimes for tiny differences early in the game. Transforming Factor Beta One (TGF-ß1) is one of the starting players in […]

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