Dupuytren Research Group Blog

Abstracts can be misleading

Unlike proximal interphalangeal joint contractures from Dupuytren’s, metacarpophalangeal joint contractures usually respond so well to fasciectomy or fasciotomy that joint capsule or ligament release is generally not a consideration. Because

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Myofibroblast Biology

Myofibroblast biology is at the heart not only of Dupuytren’s, but of other diseases not related to Dupuytren’s. Myofibroblasts are major players in pulmonary fibrosis, cirrhosis, renal fibrosis and arteriosclerosis.

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Pregnancy, Dupuytren’s and Relaxin

Relaxin is a natural hormone which does many things and normally increases during pregnancy. It has been shown to have a range of antifibrotic actions: it inhibits collagen synthesis, increases

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