Myofibroblast biology is at the heart not only of Dupuytren’s, but of other diseases not related to Dupuytren’s. Myofibroblasts are major players in pulmonary fibrosis, cirrhosis, renal fibrosis and arteriosclerosis.

Relaxin is a natural hormone which does many things and normally increases during pregnancy. It has been shown to have a range of antifibrotic actions: it inhibits collagen synthesis, increases

A very readable review of Dupuytren’s Disease from a surgeon’s perspective: http://www.dupuytrenfoundation.org/DupPDFs/1985_Hill.pdf