This is a classic article on the biology of Dupuytren’s. Structural changes in the palmar fascia are associated with type III collagen, which isn’t normally found in this tissue. Myofibroblasts are likely the source of this and are associated with disease recurrence.Most important quote: “Clinical recurrence was not related to the age of
the patient at onset, duration, or severity of disease. Recurrence was related to the electron microscopic
findings of myofibroblasts in the nodules and fibroblasts containing prominent microtubules in the fascia
of these patients.” Wouldn’t it be great to have a way to have this assessment before treatment?