Blog
Xiaflex Pricing
Auxilium has moved closer to product availability of Xiaflex collagenase injection for the treatment of Dupuytren’s contracture by announcing the wholesale drug price: $3250.00 for a single treatment dose. For those who think that this seems high, consider this in perspective. There are many categories of pharmaceutical products. Most commonly
Dupuytren’s Demographic Data
While researchers look through the microscope at the cellular biology of Dupuytren’s, surgeons look for clues using the fish eye lens of demographic observations. Who is at risk? What family, lifestyle, medication and medical condition issues affect the incidence and magnitude of Dupuytren’s? There is a long history of these
RNA, Growth Factors and Dupuytren’s
Sorting out the genetic basis of Dupuytren’s is not simply a matter of finding out which genes are involved. The goal is to understand the biochemistry of exactly what these specific genes do to either start or fail to stop the process of Dupuytren’s. Cell biology is always a domino
Dupuytren’s Diathesis
What is Dupuytren’s Diathesis? Diathesis is a medical term meaning tendency toward a condition. One way of describing a person with Dupuytren’s diathesis is that they have more of whatever Dupuytren’s is. Diathesis usually means more aggressive Dupuytren’s: earlier age of onset; more fingers involved; more often bilateral; faster progression;
Needle Aponeurotomy and Xiaflex compared
Xiaflex (Collagenase) has finally been approved by the FDA for the treatment of Dupuytren’s contracture. When work began on the development of collagenase to treat Dupuytren’s contracture, the bar was pretty low: anything better than fasciectomy in terms of either safety or efficacy would be a great advance. No other
Growing bent fingers straight
Two things are needed for people dealing with Dupuytren’s: a way to reverse or restore fingers back to their natural state and a way to prevent progression/recurrence. For the former, progress is being made; the latter remains the elusive goal of a cure. Dupuytren’s is a shrinking process. The ideal
Cellular biomechanics are the key to Dupuytren’s.
Dupuytren’s is truly a biomechanical process, and the ultimate process has to do with the way that fibroblasts and myofibroblasts attach to each other and physically attach to strands of collagen and other components of the tissue matrix which surrounds them. An investigation into the complex junction of living cells,
Fasciectomy: Unsafe at any Speed?
Fasciectomy, invented by Goyrand just a few years after Dupuytren’s initial demonstration of open fasciotomy, has been the main treatment option for Dupuytren’s for nearly 200 years. There have been many refinements, but the central theme of removing fascia is unchanged. With so much time and experience, one might assume
Frozen Shoulder, Dupuytren’s Cousin
Dupuytren’s contracture and frozen shoulder share similar biology and many people with one condition will eventually develop the other. Frozen shoulder differs from Dupuytren’s in that it is typically a painful condition with rapid onset, is more common in women and usually runs a limited course. It is similar in
Recent Dupuytren Publications
- Discussion: Frequency and Reporting of Complications after Dupuytren Contracture Interventions: A Systematic Review and Meta-Analysis
- The effect of preoperative interventions on postoperative outcomes following elective hand surgery: A systematic review
- Palmoplantar keratoderma, knuckle pads, and syndactyly associated with a new missense variant in the SLURP1 gene
- Post-traumatic Dupuytren's contracture in a paediatric patient: a case report and literature review
- Collagenase injection versus limited fasciectomy surgery to treat Dupuytren's contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation
