Dupuytren Literature: DNA

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Medline Title Search (Dupuytren + (DNA or Genetic or Genomic))

Dupuytren disease has a strong genetic component. The truth is hidden in DNA.

Selected Publications

GWAS / TWAS / Gene variants

  • Becker K, Du J, Nürnberg P, Hennies HC. Network Analysis and FineMapping GWAS Loci to Identify Genes and Functional Variants Involved in the Development of Dupuytren Disease. In: Werker P, Dias J, Eaton C, Reichert B, Wach W, eds. Dupuytren Disease and Related Diseases – The Cutting Edge. ; 2017:105-111. doi:10.1007/978-3-319-32199-8 (PDF)
  • Debniak T, Zyluk A, Puchalski P, Serrano-Fernandez P. Common variants of the EPDR1 gene and the risk of Dupuytren’s disease. Handchirurgie Mikrochirurgie Plast Chir. 2013;45(5):253–7. (PDF)
  • Dolmans GH, de Bock GH, Werker PM. Dupuytren diathesis and genetic risk. J Hand Surg Am. 2012; 37 ( 10 ):211–2106. (PDF)
  • Dolmans GH, Werker PM, Hennies HC, et al. Wnt signaling and Dupuytren’s disease. N Engl J Med. 2011;365(4):307-317. doi:10.1056/NEJMoa1101029 (PDF)
  • Dolmans GH, Werker PM, Hennies HC, et al. Supplementary Appendix: Wnt signaling and Dupuytren’s disease. N Engl J Med. 2011;365(4):307-317. doi:10.1056/NEJMoa1101029 (PDF)
  • Dolmans GHCG. Doctoral Thesis: Genetic Origin of Dupuytren’s Disease and Associated Fibromatosis. 2014:1-129. (PDF)
  • Hindocha S. Doctoral Thesis: Identification of biomarkers and whole genome scanning in Dupuytren’s Disease. A thesis submitted to the University of Manchester for the degree of Doctor of Medicine in the Faculty of Medical & Human Sciences. 2013. (PDF)
  • Ji X, Tian F, Tian L. Identification and function analysis of contrary genes in Dupuytren’s contracture. Mol Med Rep. 2015;482–8. (PDF)
  • Major M, Freund MK, Burch KS, et al. Integrative analysis of Dupuytren’s disease identifies novel risk locus and reveals a shared genetic etiology with BMI. Genet Epidemiol. 2019;43(6):629-645. doi:10.1002/gepi.22209 (PDF)
  • Ng, M., Thakkar, D., Southam, L., Werker, P., Ophoff, R., Becker, K., … Furniss, D. (2017). A Genome-wide Association Study of Dupuytren Disease Reveals 17 Additional Variants Implicated in Fibrosis. The American Journal of Human Genetics, 101(3), 417–427. http://doi.org/10.1016/j.ajhg.2017.08.006 (PDF)
  • Riesmeijer SA, Werker PMN, Nolte IM. Ethnic differences in prevalence of Dupuytren disease can partly be explained by known genetic risk variants. Eur J Hum Genet. 2019. doi:10.1038/s41431-019-0483-5 (PDF)
  • Shih B, Watson S, Bayat A. Whole genome and global expression profiling of Dupuytren’s disease: systematic review of current findings and future perspectives. Ann Rheum Dis. 2012/07/10 ed. 2012;71(9):1440-1447. (PDF)
  • Shih BB, Tassabehji M, Watson JS, McGrouther AD, Bayat A. Genome-wide high-resolution screening in Dupuytren’s disease reveals common regions of DNA copy number alterations. J Hand Surg Am. 2010; 35 ( 7 ): 1172–83 e7. (PDF)
  • Ten Dam E-JPM, van Beuge MM, Bank RA, Werker PMN. Further evidence of the involvement of the Wnt signaling pathway in Dupuytren’s disease. J Cell Commun Signal. 2016;10(1):33-40. doi:10.1007/s12079-015-0312-8 (PDF)

Sporadic

  • Anderson ER, Burmester JK, Caldwell MD. Evaluation of a mitochondrial DNA mutation in maternally inherited and sporadic cases of Dupuytren disease. Clin Med Res. 2012; 10 ( 3 ):16–122. (PDF)

Epidemiology / Genetic Risk

  • Becker K, Tinschert S, Lienert A., Bleuler PE, Staub F, Meinel A., et al. The importance of genetic susceptibility in Dupuytren’s disease. Clin Genet. 2014;1–5. (PDF)
  • Capstick R, Bragg T, Giele H, Furniss D. Sibling recurrence risk in Dupuytren’s disease . J Hand Surg Eur Vol . 2013;38(4):49-424. doi:10.1177/1753193412453359 (PDF)
  • Kuo RYL, Ng M, Prieto-Alhambra D, Furniss D. Dupuytren’s disease predicts increased all-cause and cancer-specific mortality: analysis of a large cohort from the UK Clinical Practice Research Datalink. Plast Reconstr Surg. December 2019. doi:10.1097/PRS.0000000000006551 (PDF)
  • Larsen S, Krogsgaard DG, Larsen LA, Iachina M, Skytthe A, Frederiksen H. Genetic and environmental influences in Dupuytren’s disease: A study of 30,330 Danish twin pairs. J Hand Surg Eur Vol. 2015;2014–5. (PDF)
  • Ng M, Lawson DJ, Winney B, Furniss D. Is Dupuytren’s disease really a “disease of the Vikings”? J Hand Surg Eur Vol. October 2019:1753193419882851. doi:10.1177/1753193419882851 (PDF)

Cell culture / Transcriptome

  • Bujak M, Ratkaj I, Markova-Car E, Jurišic D, Horvatic A, Vucinic S, et al. Inflammatory Gene Expression Upon TGF-ß1-Induced p38 Activation in Primary Dupuytren’s Disease Fibroblasts. Front Mol Biosci. 2015;2(December):1–9. (PDF)
  • Jung J, Kim GW, Lee B, Joo JWJ, Jang W. Integrative genomic and transcriptomic analysis of genetic markers in Dupuytren’s disease. 2019;12(Suppl 5):1-10. (PDF)
  • Liu H, Yin W, Liu B, Liu Y, Guo B, Wei Z. Screening of candidate genes in fibroblasts derived from patients with Dupuytren’s contracture using bioinformatics analysis. Rheumatol Int. Springer Berlin Heidelberg; 2015;35(8):1343–50. (PDF)

…and disputes

  • Ojwang JO, Adrianto I, Gray-McGuire C, Nath SK, Sun C, Kaufman KM, et al. Genome-wide association scan of Dupuytren’s disease. J Hand Surg Am. 2011/04/06 ed. 2010 Dec;35(12):2039–45. (PDF)
  • Furniss D, Dolmans GH, Hennies HC. Genome-wide association scan of Dupuytren’s disease. J Hand Surg Am. 2011/04/06 ed. 2011;36(4):755–6; author reply 756. (PDF)
Dupuytren Literature