DUPUYTREN LITERATURE: SPECTRUM AND OVERLAP DISEASES

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Dupuytren Spectrum Diseases

Dupuytren Spectrum Diseases include Dupuytren, Ledderhose, Peyronie, and Frozen Shoulder. They tend to cluster: people with one of these diagnoses are at greater risk of others. This suggests that these share a common genetic origin, or possibly are simply different faces of one disease. For example, people with a family history of Dupuytren disease are more likely to develop Ledderhose disease. Because of their close demographic correlation, these four diseases are likely local manifestations of an underlying systemic disorder which has yet to be identified.

• Ledderhose
• Peyronie Disease 
• Frozen Shoulder

Dupuytren Overlap Diseases

Dupuytren Overlap Diseases include pulmonary fibrosis, scleroderma, cirrhosis of the liver, psoriasis, keloid, and others. These either have biologic parallels such as pulmonary fibrosis, scleroderma, keloid, or cirrhosis, or may occur together such as psoriasis which increases the risk of Dupuytren. Overlap diseases may not be directly related, but research on one may provide insights on another. The selected publications focus on biological features rather than treatment of Dupuytren overlap diseases.

Medline Search (Dupuytren AND Psoriasis)

• Furlan A, Stramare R. The thickening of flexor tendons pulleys: a useful ultrasonographical sign in the diagnosis of psoriatic arthritis. J Ultrasound. 2018;21(4):309-314. doi:10.1007/s40477-018-0325-2 (PDF)
• Patel M, Freeman NR, Dhaliwal S, et al. The prevalence of Dupuytren contractures in patients with psoriasis. Clin Exp Dermatol. 2014;39(8):894-899. doi:10.1111/ced.12424 (PDF)

Medline Search (Dupuytren AND Pulmonary fibrosis)

• Huang C, Ogawa R. Fibroproliferative Disorders and Their Mechanobiology. Connect Tissue Res. 2012;53(3):187-196. doi:10.3109/03008207.2011.642035 (PDF)
• Noguchi H, Kephart GM, Colby T V, Gleich GJ. Tissue eosinophilia and eosinophil degranulation in syndromes associated with fibrosis. Am J Pathol. 1992;140(2):521-528. (PDF)

Medline Search (Dupuytren AND Scleroderma)

• Igarashi A, Nashiro K, Kikuchi K, et al. Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J Invest Dermatol. 1996;106(4):729-733. (PDF)
• McCarty S, Syed F, Bayat A. Role of the HLA System in the Pathogenesis of Dupuytren’s Disease. Hand (N Y). 2010;5(3):241-250. doi:10.1007/s11552-009-9255-y (PDF)
• Spencer JD, Walsh KI. Histocompatibility antigen patterns in Dupuytren’s contracture. J Hand Surg Br. 1984;9(3):276-278. (PDF)

Medline Search (Dupuytren AND Keloid)

• Calnan J. Fibrosis In Disease. Keloid And Dupuytren’s Contracture. Ann rheum Dis. 1977;36(Supplement):18-22. (PDF)
• Huang C, Ogawa R. Fibroproliferative Disorders and Their Mechanobiology. Connect Tissue Res. 2012;53(3):187-196. doi:10.3109/03008207.2011.642035 (PDF)
• Igarashi A, Nashiro K, Kikuchi K, et al. Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J Invest Dermatol. 1996;106(4):729-733. (PDF)
• Ly L, Winship I. X-linked recessive polyfibromatosis manifesting with spontaneous keloid scars and Dupuytren’s contracture . Australas J Dermatol . 2012;53(2):50-148. doi:10.1111/j.1440-0960.2011.00740.x (PDF)
• McCarty S, Syed F, Bayat A. Role of the HLA System in the Pathogenesis of Dupuytren’s Disease. Hand (N Y). 2010;5(3):241-250. doi:10.1007/s11552-009-9255-y (PDF)
• Pierpont YN, Uberti GM, Robson MC, Payne WG. Comparative Evaluation of Agents on Dupuytren’s Contracture and Keloid Fibrosis. Plast Reconstr Surg. 2012;130(5S-1 Supplement):130. (PDF)
• Tsekouras AA, McGeorge DD. Palmar fasciectomy and keloid formation. Br J Plast Surg. 1999;52(7):593-594. doi:10.1054/bjps.1999.3197 (PDF)

Medline Search (Dupuytren AND cirrhosis)

• Davidson CS, Summerskill WH, Wolfe SJ. Thickening and contraction of the palmar fascia (Dupuytren’s contracture) associated with alcoholism and hepatic cirrhosis. N Engl J Med. 1956;255(12):559-563. doi:10.1056/nejm195609202551204 (PDF)
• Noble J, Arafa M, Royle SG, McGeorge G, Crank S. The association between alcohol, hepatic pathology and Dupuytren’s disease. J Hand Surg Br. 1992;17(1):71-74. (PDF)
• O’Keefe SJ, Simjee AE, Seedat YK. Clinical presentation and biochemical abnormalities in black (Zulu) patients with cirrhosis in Durban. S Afr Med J. 1982;61(21):775-778. (PDF)
• Su CK, Patek AJ. Dupuytren’s contracture. Its association with alcoholism and cirrhosis. Arch Intern Med. 1970;126(2):278-281. doi:10.1001/archinte.1970.00310080084012 (PDF)