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The relationship between frozen shoulder (adhesive capsulitis) and Dupuytren is different than the other Dupuytren spectrum diseases. Frozen shoulder is more common in women. Frozen shoulder is more commonly painful than the other disorders. Like Dupuytren, frozen shoulder has a commonly suspected but debatable relationship with the disorder variously referred to as causalgia, complex regional pain syndrome, reflex sympathetic dystrophy, shoulder-hand syndrome, and others. The following frozen shoulder publications profile the biology rather than treatment of frozen shoulder.

Medline Search (Dupuytren AND “frozen shoulder” or “adhesive capsulitis”)

Selected Publications

  • Alhashimi R. Analytical Observational Study of Frozen Shoulder among Patients with Diabetes Mellitus. Joints. 2018;10(6):141-144. (PDF)
  • Bains M, Lambert S, Mudera V. Contractile Properties of fibroblasts derived from Primary frozen shoulder and effects of TGF beta 1 stimulation. Eur Cells Mater. 2006;11(Suppl 3):43. (PDF)
  • Balci N, Balci MK, Tuzuner S. Shoulder adhesive capsulitis and shoulder range of motion in type II diabetes mellitus: association with diabetic complications. J Diabetes Complicat. 1999;13(3):135-140. (PDF)
  • Bunker TD, Anthony PP. The pathology of frozen shoulder. A Dupuytren-like disease. J Bone Jt Surg Br. 1995;77(5):677-683. (PDF)
  • Bunker TD, Esler CN. Frozen shoulder and lipids. J Bone Joint Surg Br. 1995;77(5):684-686. Accessed October 16, 2013. (PDF)
  • Bunker TD, Reilly J, Baird KS, Hamblen DL. Expression of growth factors, cytokines and matrix metalloproteinases in frozen shoulder. J Bone Jt Surg Br. 2000;82(5):768-773. (PDF)
  • Bunker TD. Frozen shoulder: unravelling the enigma. Ann R Coll Surg Engl. 1997;79(3):210-213. (PDF)
  • Chen W, Meng J, Qian H, et al. A study of IL-1 ß, MMP-3, TGF- ß 1, and GDF5 polymorphisms and their association with primary frozen shoulder in a Chinese Han population. Biomed Res Int. 2017;2017. doi:10.1155/2017/3681645 (PDF)
  • Cho CH, Song KS, Kim BS, Kim DH, Lho YM. Biological Aspect of Pathophysiology for Frozen Shoulder. Biomed Res Int. 2018;2018. doi:10.1155/2018/7274517 (PDF)
  • Cohen C, Leal MF, Belangero PS, et al. The roles of Tenascin C and Fibronectin 1 in adhesive capsulitis : a pilot gene expression study. 2016;(5):325-331. doi:10.6061/clinics/2016(06)07 (PDF)
  • Cohen C, Leal MF, Loyola LC, et al. Genetic variants involved in extracellular matrix homeostasis play a role in the susceptibility to frozen shoulder: a case-control study. J Orthop Res. 2019;(December):1-27. doi:10.1002/jor.24228 (PDF)
  • Debeer P, Franssens F, Roosen I, Dankaerts W, Claes L. Frozen shoulder and the Big Five personality traits. J Shoulder Elb Surg. 2014;23(2):221-226. doi:10.1016/j.jse.2013.07.049 (PDF)
  • Gumina S, Candela V, Castagna A, et al. Shoulder adhesive capsulitis and hypercholesterolemia: role of APO A1 lipoprotein polymorphism on etiology and severity. Musculoskelet Surg. 2018;102(S1):35-40. doi:10.1007/s12306-018-0557-5 (PDF)
  • Hand GCR, Athanasou N a, Matthews T, Carr a J. The pathology of frozen shoulder. J Bone Joint Surg Br. 2007;89(7):928-932. doi:10.1302/0301-620X.89B7.19097 (PDF)
  • Hutchinson JW, Tierney GM, Parsons SL, Davis TR. Dupuytren’s disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor. J Bone Jt Surg Br. 1998;80(5):907-908. (PDF)
  • Kabbabe B, Ramkumar S, Richardson M. Cytogenetic analysis of the pathology of frozen shoulder. Int J Shoulder Surg. 2011;4(3):75. doi:10.4103/0973-6042.76966 (PDF)
  • Kilian O, Pfeil U, Wenisch S, Heiss C, Kraus R, Schnettler R. Enhanced alpha 1(I) mRNA expression in frozen shoulder and dupuytren tissue. Eur J Med Res. 2007;12(12):585-590. (PDF)
  • Lho YM, Ha E, Cho CH, et al. Inflammatory cytokines are overexpressed in the subacromial bursa of frozen shoulder. J Shoulder Elb Surg. 2013;22(5):666-672. doi:10.1016/j.jse.2012.06.014 (PDF)
  • Smith SP, Devaraj VS, Bunker TD. The association between frozen shoulder and Dupuytren’s disease. J shoulder Elb Surg. 2001;10(2):149-151. doi:10.1067/mse.2001.112883 (PDF)
  • Uhthoff HK, Boileau PP. Primary frozen shoulder: global capsular stiffness versus localized contracture. Clin Orthop Relat Res. 2007;456(456):79-84. doi:10.1097/BLO.0b013e318030846d (PDF)
  • Vastamaki H, Kettunen J, Vastamaki M. The natural history of idiopathic frozen shoulder: a 2- to 27-year followup study . Clin Orthop Relat Res . 2012;470(4):143-1133. doi:10.1007/s11999-011-2176-4 (PDF)
  • Wang K, Ho V, Hunter-Smith DJ, Beh PS, Smith KM, Weber AB. Risk factors in idiopathic adhesive capsulitis: a case control study. J Shoulder Elb Surg. 2013;22(7):e24-9. doi:10.1016/j.jse.2012.10.049 (PDF)
  • Xue MF, Gong SL, Dai JP, Chen G, Hu JY. The treatment of fibrosis of joint synovium and frozen shoulder by Smad4 gene silencing in rats. PLoS One. 2016;11(6):1-15. doi:10.1371/journal.pone.0158093 (PDF)
  • Zabraniecki L, Doub A, Mularczyk M, et al. Frozen shoulder: a new delayed complication of protease inhibitor therapy? Rev Rhum Engl Ed. 1998;65(1):72-74. (PDF)