DUPUYTREN LITERATURE: HYPERLIPIDEMIA
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Dupuytren Literature: Fat and Hyperlipidemia
The potential relationship between Dupuytren and adipose tissue is interesting for several reasons. Hyperlipidemia is more common in Dupuytren patients. Dupuytren is more common in underweight people, less common in overweight people. Adipokines produced by adipose tissue modulate fibrotic pathways. Palmar Dupuytren disease initially affects the superficial surface of the palmar fascia which is in continuity with subcutaneous fat but not the deep surface which is not. Dupuytren progression in the palm replaces subcutaneous fat superficial to cords with fibrous tissue, often completely, explaining the descriptive term “fibrofatty” Dupuytren tissue. Beneficial effects of subcutaneous fat injection have been reported. There’s a clue there somewhere.
Selected Publications: Lipid
- Rabinowitz JL, Ostermann L, Bora FW, Staeffen J. (1983). “Lipid Composition and de Novo Lipid Biosynthesis of Human Palmar Fat in Dupuytren’s Disease.” Lipids 18 (5): 371–74. (PDF)
- Sanderson PL, Morris MA, Stanley JK, Fahmy NR. (1992). “Lipids and Dupuytren’s Disease.” The Journal of Bone and Joint Surgery. British Volume 74 (6): 923–27. (PDF)
- Wijnen V, Frank B, Luc DS, Stefaan B, Ilse D. (2016). “Comorbidity in Dupuytren Disease.” Acta Orthop. Belg 82: 643–48. (PDF)
Selected Publications: Adipokines, Adiponectin, Adipose tissue fibrosis, adipocyte-myofibroblast transition
- Dani Christian, Pfeifer Alexander. (2017). “The Complexity of PDGFR Signaling: Regulation of Adipose Progenitor Maintenance and Adipocyte-Myofibroblast Transition.” Stem Cell Investigation 4: 28–28. (PDF)
- Hasegawa Yutaka, Ikeda Kenji, et al. (2018). “Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis.” Cell Metabolism 27 (1). Elsevier Inc.: 180–194.e6. (PDF)
- Kruglikov Ilja L, Scherer Philipp E. (2016). “Dermal Adipocytes: From Irrelevance to Metabolic Targets?” Trends in Endocrinology and Metabolism 27 (1): 1–10. (PDF)
- Kruglikov Ilja L. (2017). “Interfacial Adipose Tissue in Systemic Sclerosis.” Current Rheumatology Reports 19 (1). Current Rheumatology Reports: 1–8. (PDF)
- Long Chao, Wang Zhen, Legrand Anais, Chattopadhyay Arhana, Chang James, Fox Paige M. (2017). “Tendon Tissue Engineering: Mechanism and Effects of Human Tenocyte Coculture With Adipose-Derived Stem Cells.” The Journal of Hand Surgery. Elsevier Inc, 1–9. (PDF)
- Luo Limin, Li Jun, Liu Han, Jian Xiaoqing, Zou Qianlei, Zhao Qing, Le Qu, Chen Hongdou, Gao Xinghua, He Chundi. (2017). “Adiponectin Is Involved in Connective Tissue Growth Factor-Induced Proliferation, Migration and Overproduction of the Extracellular Matrix in Keloid Fibroblasts.” International Journal of Molecular Sciences 18 (5): 1–21. (PDF)
- Marangoni Roberta Goncalves, Korman Benjamin D, Wei Jun, Wood Tammara A, Graham Lauren V, Whitfield Michael L, Scherer Philipp E, Tourtellotte Warren G, Varga John. (2015). “Myofibroblasts in Murine Cutaneous Fibrosis Originate from Adiponectin-Positive Intradermal Progenitors.” Arthritis & Rheumatology (Hoboken, N.J.) 67 (4): 1062–73. (PDF)
- Ren Yinghui, Li Yan, et al. (2017). “Adiponectin Modulates Oxidative Stress-Induced Mitophagy and Protects C2C12 Myoblasts against Apoptosis.” Scientific Reports 7 (1). Springer US: 3209. (PDF)
- Shih Barbara, Brown Jason J, Armstrong Daniel J, Lindau Tommy, Bayat Ardeshir. (2009). “Differential Gene Expression Analysis of Subcutaneous Fat, Fascia, and Skin Overlying a Dupuytren’s Disease Nodule in Comparison to Control Tissue.” Hand 4 (3): 294–301. (PDF)
- Tooulou Monika, Demetter Pieter, Hamade Anwar, Keyzer Caroline, Nortier Joëlle L, Pozdzik Agnieszka A. (2015). “Morphological Retrospective Study of Peritoneal Biopsies from Patients with Encapsulating Peritoneal Sclerosis: Underestimated Role of Adipocytes as New Fibroblasts Lineage?” International Journal of Nephrology 2015. (PDF)
- Yang J, Lin SC, Chen G, He L, Hu Z, Chan L, Trial J, Entman ML, Wang Y. (2013). “Adiponectin Promotes Monocyte-to-Fibroblast Transition in Renal Fibrosis.” Journal of the American Society of Nephrology 24 (10): 1644–59. (PDF)
Selected Publications: Fat grafts modulating fibrosis
- Klinger M, Marazzi M, Vigo D, Torre M. (2008). “Fat Injection for Cases of Severe Burn Outcomes: A New Perspective of Scar Remodeling and Reduction.” Aesthetic Plastic Surgery 32 (3): 465–69. (PDF)
- Mentions Stahnke (unreferenced) and Lexer (LEXER, E.: Die gesamte Wiederherstellungschirurgie, Leipzig 1931, Vol. II.) reporting favorable effects of fat injection for Dupuytren. Einarsson F. (1946). “On the Treatment of Dupuytren’s Contracture.” Acta Chirurgica Scandinavica 93 (1): 1–22. http://www.ncbi.nlm.nih.gov/pubmed/21015410. (PDF)
Selected Publications: Body Mass Index
- Overweight protective: Hacquebord JH, Chiu VY, Harness NG. (2017). “The Risk of Dupuytren Surgery in Obese Individuals.” Journal of Hand Surgery 42 (3). Elsevier Inc: 149–55. (PDF)
- Underweight a risk factor: Gudmundsson KG, Arngrimsson R, Sigfusson N, Bjornsson A, Jonsson T. (2000). “Epidemiology of Dupuytren’s Disease: Clinical, Serological, and Social Assessment. The Reykjavik Study.” J Clin Epidemiol 53 (3): 291–96. (PDF)
- Increased risk after bariatric surgery: Burkard T, Lane JCE, Holmberg D, Thorell A, Burden AM, Furniss D. The association of bariatric surgery and Dupuytren’s disease: a propensity score-matched cohort study. J Hand Surg Eur Vol. 2022;47(3):288-95.
