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The greatest risk factor for developing Dupuytren disease is genetic. Other factors are associated with small increases in prevalence. These include diabetes mellitus, aging, and mechanical stress. Local tissue stress, shear plane motion, tensional homeostasis, and cyclic mechanical loading likely play roles in the cellular mechanobiology of Dupuytren. It is not known whether non-genetic factors can trigger Dupuytren contracture in those without a genetic predisposition to the disease.

Medline Title Search (Dupuytren + vibration)

  • Broekstra DC, van den Heuvel ER, Lanting R, Harder T, Smits I, Werker PMN. Dupuytren disease is highly prevalent in male field hockey players aged over 60 years. Br J Sports Med. 2016:bjsports-2016-096236. doi:10.1136/bjsports-2016-096236 (PDF)
  • Burke FD, Proud G, Lawson IJ, McGeoch KL, Miles JN V. An assessment of the effects of exposure to vibration, smoking, alcohol and diabetes on the prevalence of Dupuytren’s disease in 97,537 miners. J Hand Surg Eur Vol. 2007;32(4):400-406. doi:10.1016/j.jhse.2005.02.002 (PDF)
  • Descatha A, Bodin J, Ha C, et al. Heavy manual work, exposure to vibration and Dupuytren’s disease? Results of a surveillance program for musculoskeletal disorders . Occup Env Med . 2012;69(4):29-296. doi:10.1136/oemed-2011-100319 (PDF)
  • Descatha A, Carton M, Mediouni Z, et al. Association among work exposure, alcohol intake, smoking and Dupuytren’s disease in a large cohort study (GAZEL). BMJ Open. 2014;4(1):e004214. doi:10.1136/bmjopen-2013-004214 (PDF)
  • Fadel M, Leclerc A, Evanoff B, et al. Association between occupational exposure and Dupuytren ’ s contracture using a job-exposure matrix and self-reported exposure in the CONSTANCES cohort. 2019:1-4. doi:10.1136/oemed-2019-105912 (PDF)
  • Haines A, Levis C, Goldsmith CH, et al. Dupuytren’s contracture and handwork: A case-control study. Am J Ind Med. 2017;60(8):724-733. doi:10.1002/ajim.22736 (PDF)
  • Liss GM, Stock SR. Can Dupuytren’s contracture be work-related?: review of the evidence. Am J Ind Med. 1996;29(5):521-532. doi:10.1002/(SICI)1097-0274(199605)29:5<521::AID-AJIM12>3.0.CO;2-2 (PDF)
  • Mathieu S, Naughton G, Descatha A, Soubrier M, Dutheil F. Dupuytren’s Disease and exposure to vibration: systematic review and Meta-analysis. Jt bone spine. February 2020:100632. doi:10.1016/j.jbspin.2020.02.001 (PDF)
  • McFarlane RM. Vibration white finger and Dupuytren’s contracture: are they related? Occup Med. 1993;43(2):108. (PDF)
  • Palmer KT, D’Angelo S, Syddall H, Griffin MJ, Cooper C, Coggon D. Dupuytren’s contracture and occupational exposure to hand-transmitted vibration. Occup Environ Med. 2014;71(4):241-245. doi:10.1136/oemed-2013-101981 (PDF)
  • Thomas PR, Clarke D. Vibration white finger and Dupuytren’s contracture: are they related? Occup Med. 1992;42(3):155-158. (PDF)