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The greatest risk factor for developing Dupuytren disease is genetic. Other factors are associated with small increases in prevalence. These include diabetes mellitus, aging, and mechanical stress. Local tissue stress, shear plane motion, tensional homeostasis, and cyclic mechanical loading likely play roles in the cellular mechanobiology of Dupuytren. It is not known whether non-genetic factors can trigger Dupuytren contracture in those without a genetic predisposition to the disease.
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