Monkey model for Dupuytren’s

An experimental monkey model of Dupuytren’s Disease was performed to confirm or refute the microtrauma hypothesis of Dupuytren’s. The outcome: the reaction to rupture of the palmar fascia produced lesions identical to those of early Dupuytren’s, although did not lead to contractures during the period of study. The conclusion was that trauma is not the entire picture: “…it seems possible that certain individuals have some alteration of their connective tissues that causes these tissues to respond in an abnormal manner …to microruptures”.