Drugs that provoke Dupuytren’s Disease
Looking for ways to stop Dupuytren’s, it should be useful to look in reverse at factors which may start it, such as protease inhibitor drugs, as reported here: https://dupuytrens.org/DupPDFs/2002_Florence_1607.pdf
Dupuytren’s, Mast cells, Substance P
Dupuytren’s is not always painless. Sometimes, active areas itch and burn. This goes along with the finding of elevated levels of mast cells and nerve fibers containing substance P – something also found in interstitial cystitis. Find out more at https://dupuytrens.org/DupPDFs/2006_Schubert_1071.pdf
Aggressive Dupuytren’s Disease
This report of Dupuytren’s extending from the palm into the forearm reviews the anatomy of involvement and points out the aggressive nature of Dupuytren’s in young people. We need more effective biologic treatments: https://dupuytrens.org/DupPDFs/1997_Sinha_1048.pdf
Dupuytren’ s Contracture – Microscopic Analysis
This is a classic article on the biology of Dupuytren’s. Structural changes in the palmar fascia are associated with type III collagen, which isn’t normally found in this tissue. Myofibroblasts are likely the source of this and are associated with disease recurrence.Most important quote: “Clinical recurrence was not related to the age ofthe patient at […]
Dupuytren Symposium Website is Live!
The website for the 2010 International Symposium on Dupuytren’s Disease is now live, accepting on line registration and submission of abstracts for presentation. http://www.DupuytrenSymposium.com
Dupuytren Foundation is now a Public Charity
It’s taken almost two years to wade through the red tape, but hot off the press, The Dupuytren Foundation is finally officially certified as a 501(c)3 Public Charity! See 501(c)(3) certification for documentation.
Dupuytren’s Skin Graft Controversy
Skin grafting is a time honored technique in the range of options to reduce the incidence of recurrence after fasciectomy for Dupuytren’s contracture. There are two general approaches. One is dermofasciectomy: remove a large area of affected skin and resurface the area with a similarly large skin graft. The other is to put in a […]
Hand therapy and splinting are usually a big part of recovery after open surgery for Dupuytren’s contracture. Despite a drive for evidence based medicine, evidence for the effectiveness of splinting after open Dupuytren’s surgery is still elusive. Debbie Larson and Christina Jerosch-Herold review the issue in this article (link to full text pdf): Clinical effectiveness […]
Needle Aponeurotomy
A new option is available for people who suffer from the bent fingers of Dupuytren’s contracture allowing patients to avoid the risks, ordeal and lengthy recovery associated with traditional open surgical techniques. This quick office procedure has been practiced in France for over 30 years, and is now catching on in the USA. www.needledup.com
