Blog
A personal look at Dupuytren’s
A family physician remembers his late father’s Dupuytren’s and muses on options for treatment: http://www.greatfallstribune.com/article/20100309/LIFESTYLE/3090307/Hands+become+claws+in+victims+of+Dupuytren+s. The observation “…in his final years he was wearied by the thought of ‘another procedure’ or treatment and decided to live with the condition” is a telling testimony for the need for better treatment options
Dupuytren’s or palmar fasciitis?
Dupuytren’s isn’t the only problem which can affect the fascia of the palm. Inflammation of the palmar fascia (palmar fasciitis) may be due to less common problems, and differs from typical Dupuytren’s in that it is usually painful. The difference between Dupuytren’s and palmar fasciitis is similar to the difference
Metalloproteinases and Dupuytren’s
A better understanding of the biology of metalloproteinases may lead to new treatment options for Dupuytren’s. Metalloproteinases (MMPS) are a group of enzymes in our bodies which break down certain proteins, including collagen. MMPS are blocked by tissue inhibitors of metalloproteinases (TIMPS). MMPS and TIMPS balance each other: imbalances have
Radiotherapy for Dupuytren’s
Radiation treatment for Dupuytren’s disease has been performed since the advent of therapeutic radiation treatment. The effectiveness of radiation is reported as a preventative measure for early disease to prevent progression, not as a treatment for contracture. Although not widely embraced in the United States, there is a large European
Dupuytren’s and other fibroses
Dupuytren’s is a fibrotic disease, a fibrosis – one of many. Fibrosis, as a word, sounds exotic, but it is really just the medical name for scar. Although injuries come in many forms and can involve any structure, our bodies have a limited repertoire for reacting to injuries. The universal
Dupuytren’s: it’s not just the fascia.
Dupuytren’s contracture is a local manifestation of a systemic process, and although the palmar fascia is the usual focus, what happens in the hand is a regional process, affecting the skin and the fatty layer under the skin as well as the fascia: it appears to be something which brews
Alcohol and Dupuytren’s
Is there a relationship between drinking alcoholic beverages and the chance of having Dupuytren’s? This has been debated for years. The answer? Yes, according to the report “Dupuytren’s contracture and alcohol” (full text: https://dupuytrens.org/DupPDFs/1986_Bradlow_1148.pdf). The authors reviewed 143 patients with and without Dupuytren’s, checked their self described drinking patterns as
Is Dupuytren’s an immune problem?
Is Dupuytren’s an autoimmune or an allergic condition? In some fibrotic diseases, such as endomyocardial fibrosis, tissues show activity of eosinphils. Eosinophils are normally found in small numbers in the bloodstream. They are part of the immune system and are abnormally involved in some medical conditions such as asthma. Eosinophils
Similar genes found in Dupuytren’s and Peyronie’s
Dupuytren’s and Peyronie’s disease are believed to be related, to share a common genetic starting point. This has been an assumption, not hard fact: the genetic starting points of these conditions are not yet known, much less known to be the same. Doctors have been wrong on these issues in
Recent Dupuytren Publications
- Management of Dupuytren's Disease: A Multi-Centric Comparative Analysis Between Experienced Hand Surgeons Versus Artificial Intelligence
- Wide-Awake Partial Fasciectomy for Dupuytren Contracture: A Nationwide Analysis of Adverse Events and Reimbursement
- Public Awareness of Dupuytren's Contracture in Saudi Arabia
- Comments on: "Dupuytren's contracture: Is a history of percutaneous needle fasciotomy a risk factor for postoperative complications after secondary open fasciectomy? A retrospective study of 62 hands" by Artuso M, Protais M, Ghabcha A, Marion B, Delambre J, Aim F, published in Orthop Traumatol Surg Res 2024;104045. doi: 10.1016/j.otsr.2024.104045
- Clinical Effectiveness of an Orthosis After Collagenase Clostridium Histolyticum Injection for Dupuytren Contracture
