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A landmark advance in understanding Dupuytren’s

Two methods of investigating Dupuytren’s have been used: Demographic – family studies, associations with medications, activities, other diseases; and Biological – tissue analysis. The big biologic breakthrough came in 1972 when Gabbiani and others published two articles back to back findings on the biology of myofibroblasts: https://dupuytrens.org/DupPDFs/1971_Gabbiani.pdf and the role

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Smooth Muscle Actin in Dupuytren’s Contracture

The palmar fascia in Duputren’s contracture does not contract like a muscle: it’s more like the effect of an army of tiny rachets. Adjacent parallel strands of collagen are grabbed by myofibroblasts, which then shorten (“crimp”) lengthwise, pulling the strands to overlap more and more, and then gluing these strands

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CMMS therapy for stiffness after fasciectomy for Dupuytren’s

Stiffness is a common problem after fasciectomy, particularly loss of flexion, and can be resistant to stretching exercises or splints. This therapy program, incorporating a combination of casting and active exercises, helped patients regain motion when they had failed conventional hand therapy: https://dupuytrens.org/DupPDFs/2007_Rose.pdf

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Drugs that provoke Dupuytren’s Disease

Looking for ways to stop Dupuytren’s, it should be useful to look in reverse at factors which may start it, such as protease inhibitor drugs, as reported here: https://dupuytrens.org/DupPDFs/2002_Florence_1607.pdf

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Dupuytren’s, Mast cells, Substance P

Dupuytren’s is not always painless. Sometimes, active areas itch and burn. This goes along with the finding of elevated levels of mast cells and nerve fibers containing substance P – something also found in interstitial cystitis. Find out more at https://dupuytrens.org/DupPDFs/2006_Schubert_1071.pdf

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Aggressive Dupuytren’s Disease

This report of Dupuytren’s extending from the palm into the forearm reviews the anatomy of involvement and points out the aggressive nature of Dupuytren’s in young people. We need more effective biologic treatments: https://dupuytrens.org/DupPDFs/1997_Sinha_1048.pdf

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Dupuytren’ s Contracture – Microscopic Analysis

This is a classic article on the biology of Dupuytren’s. Structural changes in the palmar fascia are associated with type III collagen, which isn’t normally found in this tissue. Myofibroblasts are likely the source of this and are associated with disease recurrence.Most important quote: “Clinical recurrence was not related to

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Dupuytren Symposium Website is Live!

The website for the 2010 International Symposium on Dupuytren’s Disease is now live, accepting on line registration and submission of abstracts for presentation. http://www.DupuytrenSymposium.com

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