Dupuytren Literature: ADAMT Genes & ADAMTS

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  • Järveläinen H, Sainio A, Koulu M, Wight TN, Penttinen R. Extracellular matrix molecules: potential targets in pharmacotherapy. Pharmacol Rev 2009;61:198–223. (PDF)
  • Pasternak B, Aspenberg P. Metalloproteinases and their inhibitors-diagnostic and therapeutic opportunities in orthopedics. Acta Orthop 2009;80:693–703. (PDF)
  • Shih B, Bayat A. Scientific understanding and clinical management of Dupuytren disease. Nat Rev Rheumatol 2010;6:26–715. (PDF)
  • Tang BL. ADAMTS: a novel family of extracellular matrix proteases. Int J Biochem Cell Biol 2001,33:33–44. (NLM)


  • Forrester HB, Temple-Smith P, Ham S, de Kretser D, Southwick G, Sprung CN. Genome-Wide Analysis Using Exon Arrays Demonstrates an Important Role for Expression of Extra-Cellular Matrix, Fibrotic Control and Tissue Remodelling Genes in Dupuytren’s Disease. PLoS One 2013;8:e59056. (PDF)
  • Johnston P, Chojnowski AJ, Davidson RK, Riley GP, Donell ST, Clark IM. A Complete Expression Profile of Matrix-Degrading Metalloproteinases in Dupuytren’s Disease. J Hand Surg Am 2007;32:343–51. (PDF)
  • Johnston P, Larson D, Clark IM, Chojnowski AJ. Metalloproteinase gene expression correlates with clinical outcome in Dupuytren’s disease.  J Hand Surg Am 2008;33:1160–7. (PDF)
  • Wilkinson JM, Davidson RK, Swingler TE, Jones ER, Corps AN, Johnston P, et al. MMP-14 and MMP-2 are key metalloproteases in Dupuytren’s disease fibroblast-mediated contraction. Biochim Biophys Acta – Mol Basis Dis 2012;1822:897–905. (PDF)

Dupuytren Literature