These materials are available for nonprofit educational use. This repository is allowed by copyright disclaimer under title 17, Appendix E, section 107 of the United States Copyright Act. Under this statute, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. As defined, fair use specifically applies to this repository.

Medline Title Search (Dupuytren + Radiotherapy)

Radiotherapy for Dupuytren is controversial and needs further research. A nice summary of risk considerations assembled by Dr. Wolfgang Wach for the International Dupuytren Society is Risk of cancer with radiotherapy of Dupuytren Disease.pdf


Radiotherapy for Dupuytren

  • WachEstimate of the risk of cancer caused by radiation therapy of Dupuytren’s Disease.
  • Adamietz B, Keilholz L, Grünert J, Sauer R. Radiotherapy of early-stage Dupuytren disease. Long-term results after a median follow-up period of 10 years. Strahlenther Onkol. 2001;177(11):604-610. doi:10.1007/s00066-001-0852-0 (PDF)
  • Betz N, Ott OJ, Adamietz B, Sauer R, Fietkau R, Keilholz L. Radiotherapy in early-stage Dupuytren’s contracture. Long-term results after 13 years . Strahlenther Onkol . 2010;186(2):82-90. doi:10.1007/s00066-010-2063-z (PDF)
  • Eberlein B, Biedermann T. To remember: Radiotherapy – a successful treatment for early Dupuytren’s disease. J Eur Acad Dermatology Venereol. 2016;30(10):1694-1699. doi:10.1111/jdv.13773 (PDF)
  • Eng TY, Abugideiri M, Chen TW, et al. Radiation Therapy for Benign Disease: Arteriovenous Malformations, Desmoid Tumor, Dupuytren Contracture, Graves Ophthalmopathy, Gynecomastia, Heterotopic Ossification, Histiocytosis. Hematol Oncol Clin North Am. 2019;34(1):205-227. doi:10.1016/j.hoc.2019.09.005 (PDF)
  • Kadhum M, Smock E, Khan A, Fleming A. Radiotherapy in Dupuytren’s disease: a systematic review of the evidence. J Hand Surg (European Vol. 2017:175319341769599. doi:10.1177/1753193417695996 (PDF)
  • Keilholz L, Seegenschmiedt MH, Sauer R. Radiotherapy for prevention of disease progression in early-stage Dupuytren’s contracture: Initial and long-term results. Int J Radiat Oncol Biol Phys. 1996;36(4):891-897. doi:10.1016/S0360-3016(96)00421-X (PDF)
  • Keilholz L, Seegenschmiedt MH, Born AD, Sauer R. Radiotherapy in the early stage of Dupuytren’s disease. The indications, technic and long-term results. Strahlenther Onkol. 1997;173(1):27-35. (PDF)
  • Seegenschmiedt MH, Olschewski T, Guntrum F. Radiotherapy optimization in early-stage dupuytren’s contracture: First results of a randomized clinical study. Int J Radiat Oncol Biol Phys. 2001;49(3):785-798. doi:10.1016/S0360-3016(00)00745-8 (PDF)
  • Seegenschmiedt MH, Keilholz L, Wielputz M, Schubert C. Long-Term Outcome of Radiotherapy for Early Stage Dupuytren’s Disease: A Phase Ill Clinical Study. 2012;(1614):349-371. (PDF)
  • Shewring D. Dupuytren’s Disease and Radiotherapy. BSSH Corresp. 2012. (PDF)
  • Zirbs M, Anzeneder T, Bruckbauer H, et al. Radiotherapy with soft X-rays in Dupuytren’s disease – successful, well-tolerated and satisfying. J Eur Acad Dermatology Venereol. 2014:n/a-n/a. doi:10.1111/jdv.12711 (PDF)

General Hand Radiotherapy Considerations

  • Dufourmentel C, Beres J. Radiodermatitis of the hand. In: Tubiana R, ed. The Hand. Vol II. WB Saunders; 1984:849-856. (PDF)
  • Rohde RS, Puhaindran ME, Morris CD, et al. Complications of radiation therapy to the hand after soft tissue sarcoma surgery. J Hand Surg Am. 2010;35(11):1858-1863. doi:10.1016/j.jhsa.2010.08.030 (PDF)
  • Steen K, Hayward V, Novak C, Anastakis D, Mccabe S. Secondary Effects of Radiation Therapy to the Hand for Benign Conditions. 2018:1-7. doi:10.1177/1558944718810891 (PDF)

Other Radiotherapy Considerations

  • Akudugu JM, Bell RS, Catton C, et al. Wound healing morbidity in STS patients treated with preoperative radiotherapy in relation to in vitro skin fibroblast radiosensitivity, proliferative capacity and TGF-beta activity. Radiother Oncol. 2006;78(1):17-26. doi:10.1016/j.radonc.2005.12.001 (PDF)
  • Burnet NG, Nasr P, Yip G, et al. Prophylactic radiotherapy against heterotopic ossification following internal fixation of acetabular fractures: A comparative estimate of risk. Br J Radiol. 2014;87(1042). doi:10.1259/bjr.20140398 (PDF)
  • Chadwick MA, Vieten D, Pettitt E, Dixon AR, Roe AM. Short-course preoperative radiotherapy is the single most important risk factor for perineal wound complications after abdominoperineal excision of the rectum. Color Dis. 2006;8(9):756-761. doi:10.1111/j.1463-1318.2006.01029.x (PDF)
  • Chaudhry MA. Radiation-induced microRNA: Discovery, functional analysis, and cancer radiotherapy. J Cell Biochem. 2014;115(3):436-449. (PDF)
  • Eng TY, Abugideiri M, Chen TW, et al. Radiation Therapy for Benign Disease: Keloids, Macular Degeneration, Orbital Pseudotumor, Pterygium, Peyronie Disease, Trigeminal Neuralgia. Hematol Oncol Clin North Am. 2019;34(1):229-251. doi:10.1016/j.hoc.2019.09.006 (PDF)
  • Faculty of Clinical Oncology. A Review of the Use of Radiotherapy in the UK for the Treatment of Benign Clinical Conditions and Benign Tumours. London: The Royal College of Radiologists; 2015. (PDF)
  • Grenfell S, Borg M. Radiotherapy in fascial fibromatosis: A case series, literature review and considerations for treatment of early-stage disease. J Med Imaging Radiat Oncol. April 2014:1-7. doi:10.1111/1754-9485.12178 (PDF)
  • Kagan R. Back to the future reexploring radiotherapy for benign disease. Front Radiat Ther Oncol. 2001;35:18-22. (PDF)
  • Korpela E, Vesprini D, Liu SK. MicroRNA in radiotherapy: miRage or miRador? Br J Cancer. 2015;112(5):777-782. doi:10.1038/bjc.2015.6 (PDF)
  • McKeown SR, Hatfield P, Prestwich RJ, Shaffer RE, Taylor RE. Radiotherapy for benign disease; assessing the risk of radiation-induced cancer following exposure to intermediate-dose radiation. Br J Radiol. 2015;88(1056):20150405. (PDF)
  • Milakovic M, Popovic M, Raman S, Tsao M, Lam H, Chow E. Radiotherapy for the prophylaxis of heterotopic ossification: A systematic review and meta-analysis of randomized controlled trials. Radiother Oncol. 2015;116(1):4-9. (PDF)
  • O’Dea FJ, Wunder J, Bell RS, Griffin a M, Catton C, O’Sullivan B. Preoperative radiotherapy is effective in the treatment of fibromatosis. Clin Orthop Relat Res. 2003;(415):19-24. doi:10.1097/01.blo.0000093892.12372.d4 (PDF)
  • Ott OJ, Niewald M, Weitmann HD, et al. DEGRO guidelines for the radiotherapy of non-malignant disorders. Part II: Painful degenerative skeletal disorders. Strahlenther Onkol. 2015;191(1):1-6. doi:10.1007/s00066-014-0757-3 (PDF)
  • Ploumis A, Belbasis L, Ntzani E, Tsekeris P, Xenakis T. Radiotherapy for prevention of heterotopic ossification of the elbow: A systematic review of the literature. J Shoulder Elb Surg. 2013;22(11):1580-1588.  (PDF)
  • Popovic M, Agarwal A, Zhang L, et al. Radiotherapy for the prophylaxis of heterotopic ossification: A systematic review and meta-analysis of published data. Radiother Oncol. 2014;113(1):10-17. (PDF)
  • Robijns J, Censabella S, Claes S, et al. Prevention of acute radiodermatitis by photobiomodulation: A randomized, placebo-controlled trial in breast cancer patients (TRANSDERMIS trial). Lasers Surg Med. 2018;9(January):1-9. (PDF)
  • Ruo Redda MG, De Colle C, Bianco L, et al. Heterotopic ossifications: role of radiotherapy as prophylactic treatment. Radiol Medica. 2018;123(6):463-468. (PDF)
  • Seegenschmiedt MH, Keilholz L, Martus P, et al. Prevention of heterotopic ossification about the hip: final results of two randomized trials in 410 patients using either preoperative or postoperative radiation therapy. Int J Radiat Oncol Biol Phys. 1997;39(1):161-171. doi:S036030169700285X (PDF)
  • Shapeero LG, De Visschere PJL, Verstraete KL, et al. Post-treatment complications of soft tissue tumours. Eur J Radiol. 2009;69(2):209-221. (PDF)
  • Taylor RE, Hatfield P, McKeown SR, Prestwich RJD, Shaffer R. Radiotherapy for Benign Disease: Current Evidence, Benefits and Risks. Clin Oncol (R Coll Radiol). 2015:9-11. doi:10.1016/j.clon.2015.01.009 (PDF)
  • Templin T, Paul S, Amundson SA, et al. Radiation-induced micro-RNA expression changes in peripheral blood cells of radiotherapy patients. Int J Radiat Oncol Biol Phys. 2011;80(2):549-557. (PDF)
  • Withers R, Mcbride WH. Cellular Effects of Radiotherapy for Benign Disease. In: Meyer J, ed. The Radiation Therapy of Benign Diseases. Current Indications and Techniques. Front Radiat Ther Oncol. Vol 35. Basel: Karger; 2001:23-29. (PDF)