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Medline Title Search (Dupuytren + Radiotherapy)

Radiotherapy for Dupuytren is controversial and needs further research. A nice summary of risk considerations assembled by Dr. Wolfgang Wach for the International Dupuytren Society is Risk of cancer with radiotherapy of Dupuytren Disease.pdf


Radiotherapy for Dupuytren

  • WachEstimate of the risk of cancer caused by radiation therapy of Dupuytren’s Disease.
  • Adamietz B, Keilholz L, Grünert J, Sauer R. Radiotherapy of early-stage Dupuytren disease. Long-term results after a median follow-up period of 10 years. Strahlenther Onkol. 2001;177(11):604-610. doi:10.1007/s00066-001-0852-0 (PDF)
  • Betz N, Ott OJ, Adamietz B, Sauer R, Fietkau R, Keilholz L. Radiotherapy in early-stage Dupuytren’s contracture. Long-term results after 13 years . Strahlenther Onkol . 2010;186(2):82-90. doi:10.1007/s00066-010-2063-z (PDF)
  • Eberlein B, Biedermann T. To remember: Radiotherapy – a successful treatment for early Dupuytren’s disease. J Eur Acad Dermatology Venereol. 2016;30(10):1694-1699. doi:10.1111/jdv.13773 (PDF)
  • Eng TY, Abugideiri M, Chen TW, et al. Radiation Therapy for Benign Disease: Arteriovenous Malformations, Desmoid Tumor, Dupuytren Contracture, Graves Ophthalmopathy, Gynecomastia, Heterotopic Ossification, Histiocytosis. Hematol Oncol Clin North Am. 2019;34(1):205-227. doi:10.1016/j.hoc.2019.09.005 (PDF)
  • Kadhum M, Smock E, Khan A, Fleming A. Radiotherapy in Dupuytren’s disease: a systematic review of the evidence. J Hand Surg (European Vol. 2017:175319341769599. doi:10.1177/1753193417695996 (PDF)
  • Keilholz L, Seegenschmiedt MH, Sauer R. Radiotherapy for prevention of disease progression in early-stage Dupuytren’s contracture: Initial and long-term results. Int J Radiat Oncol Biol Phys. 1996;36(4):891-897. doi:10.1016/S0360-3016(96)00421-X (PDF)
  • Keilholz L, Seegenschmiedt MH, Born AD, Sauer R. Radiotherapy in the early stage of Dupuytren’s disease. The indications, technic and long-term results. Strahlenther Onkol. 1997;173(1):27-35. (PDF)
  • Seegenschmiedt MH, Olschewski T, Guntrum F. Radiotherapy optimization in early-stage dupuytren’s contracture: First results of a randomized clinical study. Int J Radiat Oncol Biol Phys. 2001;49(3):785-798. doi:10.1016/S0360-3016(00)00745-8 (PDF)
  • Seegenschmiedt MH, Keilholz L, Wielputz M, Schubert C. Long-Term Outcome of Radiotherapy for Early Stage Dupuytren’s Disease: A Phase Ill Clinical Study. 2012;(1614):349-371. (PDF)
  • Shewring D. Dupuytren’s Disease and Radiotherapy. BSSH Corresp. 2012. (PDF)
  • Zirbs M, Anzeneder T, Bruckbauer H, et al. Radiotherapy with soft X-rays in Dupuytren’s disease – successful, well-tolerated and satisfying. J Eur Acad Dermatology Venereol. 2014:n/a-n/a. doi:10.1111/jdv.12711 (PDF)

General Hand Radiotherapy Considerations

  • Dufourmentel C, Beres J. Radiodermatitis of the hand. In: Tubiana R, ed. The Hand. Vol II. WB Saunders; 1984:849-856. (PDF)
  • Rohde RS, Puhaindran ME, Morris CD, et al. Complications of radiation therapy to the hand after soft tissue sarcoma surgery. J Hand Surg Am. 2010;35(11):1858-1863. doi:10.1016/j.jhsa.2010.08.030 (PDF)
  • Steen K, Hayward V, Novak C, Anastakis D, Mccabe S. Secondary Effects of Radiation Therapy to the Hand for Benign Conditions. 2018:1-7. doi:10.1177/1558944718810891 (PDF)

Other Radiotherapy Considerations

  • Akudugu JM, Bell RS, Catton C, et al. Wound healing morbidity in STS patients treated with preoperative radiotherapy in relation to in vitro skin fibroblast radiosensitivity, proliferative capacity and TGF-beta activity. Radiother Oncol. 2006;78(1):17-26. doi:10.1016/j.radonc.2005.12.001 (PDF)
  • Burnet NG, Nasr P, Yip G, et al. Prophylactic radiotherapy against heterotopic ossification following internal fixation of acetabular fractures: A comparative estimate of risk. Br J Radiol. 2014;87(1042). doi:10.1259/bjr.20140398 (PDF)
  • Chadwick MA, Vieten D, Pettitt E, Dixon AR, Roe AM. Short-course preoperative radiotherapy is the single most important risk factor for perineal wound complications after abdominoperineal excision of the rectum. Color Dis. 2006;8(9):756-761. doi:10.1111/j.1463-1318.2006.01029.x (PDF)
  • Chaudhry MA. Radiation-induced microRNA: Discovery, functional analysis, and cancer radiotherapy. J Cell Biochem. 2014;115(3):436-449. (PDF)
  • Eng TY, Abugideiri M, Chen TW, et al. Radiation Therapy for Benign Disease: Keloids, Macular Degeneration, Orbital Pseudotumor, Pterygium, Peyronie Disease, Trigeminal Neuralgia. Hematol Oncol Clin North Am. 2019;34(1):229-251. doi:10.1016/j.hoc.2019.09.006 (PDF)
  • Faculty of Clinical Oncology. A Review of the Use of Radiotherapy in the UK for the Treatment of Benign Clinical Conditions and Benign Tumours. London: The Royal College of Radiologists; 2015. (PDF)
  • Grenfell S, Borg M. Radiotherapy in fascial fibromatosis: A case series, literature review and considerations for treatment of early-stage disease. J Med Imaging Radiat Oncol. April 2014:1-7. doi:10.1111/1754-9485.12178 (PDF)
  • Kagan R. Back to the future reexploring radiotherapy for benign disease. Front Radiat Ther Oncol. 2001;35:18-22. (PDF)
  • Korpela E, Vesprini D, Liu SK. MicroRNA in radiotherapy: miRage or miRador? Br J Cancer. 2015;112(5):777-782. doi:10.1038/bjc.2015.6 (PDF)
  • McKeown SR, Hatfield P, Prestwich RJ, Shaffer RE, Taylor RE. Radiotherapy for benign disease; assessing the risk of radiation-induced cancer following exposure to intermediate-dose radiation. Br J Radiol. 2015;88(1056):20150405. (PDF)
  • Milakovic M, Popovic M, Raman S, Tsao M, Lam H, Chow E. Radiotherapy for the prophylaxis of heterotopic ossification: A systematic review and meta-analysis of randomized controlled trials. Radiother Oncol. 2015;116(1):4-9. (PDF)
  • O’Dea FJ, Wunder J, Bell RS, Griffin a M, Catton C, O’Sullivan B. Preoperative radiotherapy is effective in the treatment of fibromatosis. Clin Orthop Relat Res. 2003;(415):19-24. doi:10.1097/01.blo.0000093892.12372.d4 (PDF)
  • Ott OJ, Niewald M, Weitmann HD, et al. DEGRO guidelines for the radiotherapy of non-malignant disorders. Part II: Painful degenerative skeletal disorders. Strahlenther Onkol. 2015;191(1):1-6. doi:10.1007/s00066-014-0757-3 (PDF)
  • Ploumis A, Belbasis L, Ntzani E, Tsekeris P, Xenakis T. Radiotherapy for prevention of heterotopic ossification of the elbow: A systematic review of the literature. J Shoulder Elb Surg. 2013;22(11):1580-1588.  (PDF)
  • Popovic M, Agarwal A, Zhang L, et al. Radiotherapy for the prophylaxis of heterotopic ossification: A systematic review and meta-analysis of published data. Radiother Oncol. 2014;113(1):10-17. (PDF)
  • Robijns J, Censabella S, Claes S, et al. Prevention of acute radiodermatitis by photobiomodulation: A randomized, placebo-controlled trial in breast cancer patients (TRANSDERMIS trial). Lasers Surg Med. 2018;9(January):1-9. (PDF)
  • Ruo Redda MG, De Colle C, Bianco L, et al. Heterotopic ossifications: role of radiotherapy as prophylactic treatment. Radiol Medica. 2018;123(6):463-468. (PDF)
  • Seegenschmiedt MH, Keilholz L, Martus P, et al. Prevention of heterotopic ossification about the hip: final results of two randomized trials in 410 patients using either preoperative or postoperative radiation therapy. Int J Radiat Oncol Biol Phys. 1997;39(1):161-171. doi:S036030169700285X (PDF)
  • Shapeero LG, De Visschere PJL, Verstraete KL, et al. Post-treatment complications of soft tissue tumours. Eur J Radiol. 2009;69(2):209-221. (PDF)
  • Taylor RE, Hatfield P, McKeown SR, Prestwich RJD, Shaffer R. Radiotherapy for Benign Disease: Current Evidence, Benefits and Risks. Clin Oncol (R Coll Radiol). 2015:9-11. doi:10.1016/j.clon.2015.01.009 (PDF)
  • Templin T, Paul S, Amundson SA, et al. Radiation-induced micro-RNA expression changes in peripheral blood cells of radiotherapy patients. Int J Radiat Oncol Biol Phys. 2011;80(2):549-557. (PDF)
  • Withers R, Mcbride WH. Cellular Effects of Radiotherapy for Benign Disease. In: Meyer J, ed. The Radiation Therapy of Benign Diseases. Current Indications and Techniques. Front Radiat Ther Oncol. Vol 35. Basel: Karger; 2001:23-29. (PDF)